Composto da Cannabis Mostra Potencial Antienvelhecimento e de Melhora Cognitiva, Diz Estudo

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Um estudo recente sugere que a administração de longo prazo de baixas doses de Δ9-THC, o principal componente psicoativo da cannabis, pode servir de base para o desenvolvimento de tratamentos eficazes contra o envelhecimento e para a melhoria cognitiva. Publicado na revista Pharmacology and Translational Science da Sociedade Americana de Química, a pesquisa destaca aumentos significativos na energia e na produção de proteínas sinápticas em camundongos idosos tratados com Δ9-THC.

O estudo, financiado pelo governo alemão no contexto da nova política de legalização da cannabis no país, revela que o Δ9-THC em doses baixas pode reverter o declínio cognitivo relacionado à idade. Os pesquisadores observaram que, em camundongos mais velhos, o THC aumentou a atividade de mTOR, uma proteína crucial para a função cognitiva e para processos celulares ligados ao envelhecimento. Essa atividade levou à formação e reparação de sinapses, especialmente no hipocampo, uma região do cérebro associada ao aprendizado e à memória

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Os pesquisadores também descobriram que o THC desencadeou um efeito de fase dupla. Inicialmente, aumentou a atividade de mTOR e a mobilização de energia no cérebro, promovendo o crescimento sináptico. Isso foi seguido por uma redução da atividade de mTOR no tecido adiposo, o que contribuiu para efeitos antienvelhecimento ao diminuir os processos metabólicos. Esse duplo efeito pode abrir caminho para o desenvolvimento de medicamentos que não apenas melhorem a cognição, mas também combatam o envelhecimento.

É importante notar que o estudo observou efeitos dependentes da idade. Enquanto os camundongos mais velhos se beneficiaram com a melhora das habilidades cognitivas, os mais jovens experimentaram efeitos adversos, como comprometimento da memória. Isso está em linha com pesquisas anteriores que também indicaram resultados diferentes do tratamento com THC dependendo da idade.

Siga-nos no Instagram, tem ainda mais coisas interessantes lá.

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