The researchers also found that THC triggered a dual-phase effect. Initially, it increased mTOR activity and energy mobilization in the brain, promoting synaptic growth. This was followed by reduced mTOR activity in adipose tissue, which contributed to anti-aging effects by decreasing metabolic processes. Such a dual effect may pave the way for the development of drugs that not only enhance cognition but also combat aging.
Importantly, the study noted age-dependent effects of THC. While older mice benefited from improved cognitive abilities, younger mice experienced adverse effects, such as memory impairment. This aligns with previous research that also indicated different outcomes of THC treatment based on age.
The findings suggest that low-dose Δ9-THC could offer a novel approach to treating brain aging, potentially leading to breakthroughs in anti-aging and cognitive enhancement therapies.
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